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自从 Waldenstr(?)m 1950年首先描述慢性活动性肝炎(chronic active hepatitis,CAH)以来,许多学者一直在探讨该病的病因和发病机制。某些病例显然是继发于病毒性肝炎或长期使用药物,但部分病例仍然起因不明。此类病人多不同程度地存在自身免疫现象,例如:高γ-球蛋白血症和自身抗体等,提示有自身免疫反应参与。1964年首次发现人白细胞抗原系统(hu-man leucocytic antigen,HLA)与疾病之间存在某种关系。近年来,许多学者相继发现 CAH 与某些 HLA 有关联, 认为部分 CAH 的发生和发展受遗传因素的影响。虽然这种相关联的研究还是初步,而且各家报道的结果不尽相符,
Since Waldenstr (?) M first described chronic active hepatitis (CAH) in 1950, many scholars have been exploring the etiology and pathogenesis of the disease. Some cases apparently secondary to viral hepatitis or long-term use of drugs, but some cases still cause unknown. Such patients with varying degrees of autoimmune phenomena, such as: high γ-globulin and autoantibodies, suggesting that autoimmune reactions involved. It was first discovered in 1964 that there was a relationship between the human leucocytic antigen (HLA) and the disease. In recent years, many scholars have found that CAH associated with some HLA, that part of the occurrence and development of CAH affected by genetic factors. Although this kind of related research is still preliminary, and the results of various reports do not match,