论文部分内容阅读
目的:观察复方补筋片对肾虚血瘀型膝骨性关节炎患者血清和关节液中IL-1β、TNF-α水平的影响,探讨复方补筋片的作用机理,为本院制剂的推广与开发应用提供科学依据。方法:收集漳州市中医院2010年6月～2011年6月骨伤科门诊和康复科门诊就诊符合纳入条件的肾虚血瘀型膝骨性关节炎患者,共60例。将纳入患者用随机数字表分为两组,治疗组口服漳州市中医院本院制剂复方补筋片;对照组口服壮骨关节丸组,治疗周期均为4周,所有患者分别在治疗前及治疗周期结束1周内测定血清和关节液中IL-1β、TNF-α含量。结果:1.在降低肾虚血瘀型膝骨性关节炎患者血清和关节液中IL-1β、TNF-α含量比较,(P<0.05),有差异性,治疗组疗效优于对照组。2.治疗组与对照组在临床疗效方面比较,(P<0.05),有差异性,治疗组疗效优于对照组。结论:复方补筋片可能通过降低关节滑液中IL-1β、TNF-α含量,从而保护膝关节软骨及软骨下骨、改善膝骨性关节炎患者的症状。
OBJECTIVE: To observe the effect of compound supplement tablets on the levels of IL-1β and TNF-α in serum and synovial fluid of patients with knee osteoarthritis of kidney deficiency and blood stasis type, and to explore the mechanism of action of compound supplement tablets. Development and application of scientific basis. Methods: A total of 60 patients with knee osteoarthritis of kidney deficiency and blood stasis type were enrolled in the Department of Orthopedics and Rehabilitation Medicine of Zhangzhou Hospital of Traditional Chinese Medicine from June 2010 to June 2011. Will be included in the patient with random number table is divided into two groups, the treatment group oral Zhangzhou City Hospital of Chinese medicine compound prescription tablets; the control group oral Zhuanggu joint pill group, the treatment cycle were 4 weeks, all patients were treated before and The levels of IL-1β and TNF-α in serum and synovial fluid were determined within 1 week after the end of the treatment period. Compared with the control group, the levels of IL-1β and TNF-αin the serum and synovial fluid of patients with knee osteoarthritis were significantly lower than those of the control group (P <0.05). The treatment group and the control group in the clinical efficacy comparison (P <0.05), there are differences, the treatment group than the control group. CONCLUSION: Fufangbu tablets can protect the knee joint cartilage and subchondral bone and improve the symptoms of knee osteoarthritis patients by reducing the content of IL-1β and TNF-α in synovial fluid.