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白色念珠菌引起的感染不但与多种毒力因素及宿主防御功能缺陷有关,也与免疫病理状态有关。并已证明,Th_2细胞所释放的抑制性细胞因子能抑制Th细胞及效应细胞。在全身性白色念珠菌感染的小鼠经抗体中和IL-4及IL-10能诱发保护性的Th_1细胞应答。本文对可溶性白介素-4受体(sIL-4R)在念珠菌病的作用进行了研究。以高度致病性的白色念珠菌CA-6株全身感染CD2F1小鼠,利用沙保右旋糖琼脂平板作平板稀释法测定鼠肾内活菌数。常规尸检以证明全身感染。以10~8个CA-6活菌经口
Infection caused by Candida albicans not only with a variety of virulence factors and host defense dysfunction, but also with the immune pathological state. And it has been demonstrated that the inhibitory cytokines released by Th2 cells can inhibit Th cells and effector cells. Systemic Candida albicans infection in mice neutralizing IL-4 and IL-10 induced a protective Thl cell response. The role of soluble interleukin-4 receptor (sIL-4R) in candidiasis was studied in this article. CD2F1 mice were infected with highly pathogenic Candida albicans strain CA-6, and the viable count in the kidney of mice was determined by the saponin dextran agar plate. Regular autopsy to prove systemic infection. To 10 to 8 CA-6 live via the mouth