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目的通过不同时间窗观察东菱克栓酶对脑梗塞患者的疗效及不良反应，寻找该药治疗脑梗塞的最佳时间及可能避免继发出血的方法。方法将５０例脑梗塞患者随机分成治疗组及对照组。治疗组按不同时间窗分３组（１２内，１２～７２ｈ，７２ｈ～ ７ｄ）。治疗组给予东菱克栓酶 ３０ＢＵ治疗（第 １，２，３．４ｄ分别用 １０ＢＵ，１０ＢＵ，ＳＢＵ，ＳＢＵ），对照组用低分子右旋糖酐和丹参治疗。观察各组疗效及不良反应，并做实验室及影像学检查。结果各时间窗疗效较对照组均有显著差异。治疗组ＦＩＢ明显降低，而对其他凝血指标无明显影响。结论１周内使用东菱克栓酶均有明显效果，使用２０ＢＵ后，及时复查ＦＩＢ并调整用药可减少出血倾向。
Objective To observe the curative effect and side effects of citrullinated cord hydrolase in patients with cerebral infarction through different time windows and to find out the best time for this medicine in treating cerebral infarction and the possible method to avoid secondary hemorrhage. Methods Fifty patients with cerebral infarction were randomly divided into treatment group and control group. The treatment group according to different time window divided into 3 groups (12, 12 ~ 72h, 72h ~ 7d). The treatment group was treated with 30GU of rhubarb and fibrinolytic enzyme (10BU, 10BU, SBU and SBU respectively on the 1st, 2nd and 4th day). The control group was treated with low molecular dextran and Salvia miltiorrhiza. Observed the curative effect and adverse reaction of each group, and did laboratory and imaging examination. Results The curative effect of each time window was significantly different from the control group. The treatment group FIB decreased significantly, while no significant effect on other coagulation parameters. Conclusion 1 week using rhubarb bolt enzyme have a significant effect, the use of 20BU, timely review of FIB and adjust the medication can reduce bleeding tendency.