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目的研究柯萨奇Ｂ病毒（ＣＢＶ）感染对孕产妇、围生儿的影响。方法应用间接免疫荧光法测定１６１例孕产妇及１８０例非孕育龄妇女血清ＣＢＶ特异性ＩｇＭ抗体。结果ＣＢＶ感染４６例，占１３．５％（４６／３４１），１６１例孕产妇采集了孕早期标本１０３例，孕中期８６例，孕晚期１５２例，ＣＢＶ阳性分别为７例（６．８％）、６例（７％）和２４例（１５．８％），１５２例脐血无１例阳性。１６１例早期新生儿无ＣＢＶ感染症状。结论孕产妇感染ＣＢＶ经胎盘垂直传播可能小，但检测ＣＢＶＩｇＭ对控制病源垂直传播和水平传播提供了证据。
Objective To study the effects of coxsackie virus (CBV) infection on pregnant women and perinatal children. Methods Serum samples of CBV-specific IgM were detected in 161 pregnant women and 180 non-pregnant women by indirect immunofluorescence assay. Results CBV infection was found in 46 cases, accounting for 13.5% (46/341). Among the 161 pregnant women, 103 pregnant women were enrolled in the early pregnancy, 86 in the second trimester and 152 in the third trimester. The positive rates of CBV were 7 (6.8% ), 6 cases (7%) and 24 cases (15.8%). No one of 152 cases of cord blood was positive. 161 cases of early neonatal CBV infection without symptoms. Conclusion The placental transmission of CBV in pregnant women may be small, but the detection of CBVIgM may provide evidence for the control of vertical and horizontal transmission of pathogens.