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目的:探讨子宫肌瘤复发患者FAS和FAS-L的表达水平及其临床意义。方法:随机选择子宫肌瘤剔除术后复发患者,取其首次剔除的肌瘤组织、瘤旁正常子宫平滑肌组织和复发剔除的肌瘤组织、瘤旁正常子宫平滑肌组织的病理存档蜡块各100例。采用免疫组织化学方法检测首次肌瘤组织、瘤旁正常子宫平滑肌组织和复发肌瘤组织、瘤旁正常子宫平滑肌组织中FAS和FAS-L的蛋白表达水平。结果:复发瘤旁正常子宫平滑肌组织中FAS和FAS-L的蛋白表达水平低于首次瘤旁正常子宫平滑肌组织,差异有统计学意义(P<0.05)。与瘤旁正常子宫平滑肌组织比较,首次和复发的肌瘤组织FAS、FAS-L的蛋白表达水平均明显降低,差异有统计学意义(P<0.01);且复发肌瘤组织中FAS和FAS-L的蛋白表达水平明显低于首次肌瘤组织,差异有统计学意义(P<0.01)。结论:FAS和FAS-L参与了子宫肌瘤的复发,与子宫肌瘤的复发有密切的关系。
Objective: To investigate the expression of FAS and FAS-L in patients with recurrent uterine fibroids and its clinical significance. Methods: Patients with recurrence of uterine fibroids were selected randomly, and the pathological paraffin blocks were collected from the first excised fibroid tissue, the normal para-normal uterine smooth muscle tissue and the recurrence-removed myoma tissue, and the para-normal uterine smooth muscle tissue . Immunohistochemistry was used to detect the protein expression of FAS and FAS-L in primary myometrium, normal uterine smooth muscle and recurrence myoma, adjacent normal uterine smooth muscle. Results: The protein expression of FAS and FAS-L in the normal uterine smooth muscle tissue adjacent to the tumor was lower than that in the first normal uterine smooth muscle tissue, with significant difference (P <0.05). Compared with normal uterine smooth muscle, the protein expression of FAS and FAS-L in the first and recurrent fibroids were significantly lower (P <0.01), and the levels of FAS and FAS- L protein expression was significantly lower than the first fibroid tissue, the difference was statistically significant (P <0.01). Conclusion: FAS and FAS-L are involved in the recurrence of uterine fibroids and are closely related to the recurrence of uterine fibroids.