肿瘤细胞的抗药机制涉及多方面因素,其中之一为MDRI基因的产物-P糖蛋白(Pgp)表达量升高。作者采用新近研制的单克隆抗体-UIC2,应用免疫组化方法,对10例头颈部鳞癌患者石腊包埋切片的Pgp表达进行了检测。结果60％的标本中Pgp染色阳性,并与肿瘤分化程度相关(分化越高,Pgp表达量越多),但与 The resistance mechanism of tumor cells involves many factors, one of which is the product of MDRI gene-Pgp expression. Using the newly developed monoclonal antibody-UIC2, the immunohistochemistry method was used to detect Pgp expression in paraffin-embedded sections of 10 head and neck squamous cell carcinoma patients. Results Pgp staining was positive in 60% of the specimens and correlated with the degree of tumor differentiation (the higher the differentiation, the more Pgp expression), but with