脊髓损伤(spinal cord injury,SCI)发病率逐年升高,治疗棘手,预后差,给社会和家庭带来重大的负担。有关脊髓损伤动物模型的研究也在不断发展。1脊髓直接损伤模型1.1脊髓撞击损伤模型Allen等[1]最早建立了重物坠落致SCI的模型,即重物坠落法(weight drop,WD)。用一定重量的重锤沿一个套管垂直落下打击特定脊髓节段而致伤。脊髓致伤能量采用重物质量(g)与下落高度(cm)的乘积来衡量。此方法简单易行,制作成本低,易于复制,可通过调整重锤的重量和坠落高度来改变撞击能量,也可通过调整 The incidence of spinal cord injury (SCI) is increasing year by year. The treatment is difficult and the prognosis is poor, which puts a heavy burden on society and families. Research on animal models of spinal cord injury is also evolving. 1 Spinal Cord Injury Model 1.1 Spinal Cord Injury Model Allen et al. [1] established the model of SCI caused by heavy fall first, namely weight drop (WD). With a certain weight of the hammer down along a vertical tube to hit a specific spinal cord injury. Spinal cord injury energy is measured as the product of weight (g) and drop height (cm). This method is simple, low production costs, easy to copy, by adjusting the weight of the hammer and fall height to change the impact energy can also be adjusted