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目的锌转运体8(ZnT8)与胰岛素等激素的分泌有关,但其在睾丸的功能尚不清楚,本实验旨在探讨ZnT8在小鼠睾丸的分布与功能。方法通过免疫组织化学技术检测成年雄性小鼠睾丸ZnT8的分布;乳鼠腹腔注射hCG(human chorionic gonadotrophin,人绒毛膜促性腺激素),注射5d后,检测乳鼠睾丸ZnT8的分布;化学发光法检测乳鼠血清睾酮水平。结果 ZNT8主要分布在成年雄鼠睾丸间质细胞,hCG处理乳鼠在血清睾酮升高的同时伴有睾丸间质细胞ZnT8表达增加。结论 ZnT8的功能可能与小鼠睾丸间质细胞睾酮合成有关。
Purpose Zinc transporter 8 (ZnT8) is associated with the secretion of insulin and other hormones, but its function in testis is unclear. The purpose of this study is to investigate the distribution and function of ZnT8 in mouse testis. Methods The distribution of ZnT8 in testes of adult male mice was detected by immunohistochemistry. The distribution of ZnT8 in testis of neonatal rats was detected by intraperitoneal injection of hCG (human chorionic gonadotrophin) Serum testosterone levels in suckling mice. Results ZNT8 mainly distributed in testicular stromal cells of adult male rats. The expression of ZnT8 in testicular stromal cells was increased with the increase of serum testosterone in hCG-treated neonatal rats. Conclusion The function of ZnT8 may be related to testosterone synthesis in mouse testicular stromal cells.