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目的 :探讨腹腔化疗对大肠癌患者手术后免疫功能状况的影响。方法 :对 1 997年 1月至 2 0 0 2年 1 2月行根治性手术的4 8例大肠癌患者进行腹腔化疗前后细胞免疫功能检测 ,并将之与同期健康对照组和行静脉化疗病例进行比较。所有患者于化疗前 1d和化疗后 7d早晨空腹时静脉采血 ,测定血清中NK细胞和T细胞亚群。结果 :大肠癌患者手术后CD4和NK细胞水平明显低于健康人群 ;大肠癌患者化疗后CD4、CD4 /CD8和NK细胞水平低于化疗前 ,其中静脉化疗患者化疗后较化疗前明显降低 ,存在统计学意义 (P <0 0 5 ) ;而腹腔化疗组患者化疗前后上述指标的变化不大 ,无统计学意义 (P >0 0 5 )。结论 :针对大肠癌患者的免疫特点 ,采用对细胞免疫抑制较轻的腹腔化疗方式进行化疗 ,有利于大肠癌患者细胞免疫功能的恢复。
Objective: To investigate the effect of intraperitoneal chemotherapy on immune function in patients with colorectal cancer after operation. Methods: Forty-eight patients with colorectal cancer who underwent radical surgery between January 1997 and February 2002 were evaluated for cellular immune function before and after intraperitoneal chemotherapy and compared with healthy controls and intravenous chemotherapy Compare. All patients on the first day before chemotherapy and 7d after chemotherapy on the morning fasting venous blood samples were measured serum NK cells and T cell subsets. Results: The levels of CD4 and NK cells in patients with colorectal cancer after operation were significantly lower than those in healthy people. The levels of CD4, CD4 / CD8 and NK cells in patients with colorectal cancer after chemotherapy were lower than those before chemotherapy. (P <0.05). However, there was no significant change in the above indexes before and after chemotherapy in patients with intraperitoneal chemotherapy (P> 0.05). Conclusions: According to the immunological characteristics of patients with colorectal cancer, chemotherapy of intraperitoneal chemotherapy with less immunosuppression is helpful for the recovery of cellular immune function in patients with colorectal cancer.