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冠状动脉血管成型术后的再狭窄是心血管病防治研究的一个重点和热点，本文结合我们研究所近5年来的研究工作和国内外研究进展，就再狭窄形成的细胞和分子生物学机制，分为再狭窄的形成过程、生物活性物质和生长因子、平滑肌细胞增殖和凋亡、细胞信息传递和转录调节、癌基因和抗癌基因及再狭窄的基因治疗等六个方面进行较系统和全面的综述。
Restenosis after coronary angioplasty is a focus and hotspot in the study of prevention and treatment of cardiovascular diseases. Based on the research work of our institute and the research progress at home and abroad in recent 5 years, this paper reviewed the cellular and molecular biological mechanisms of restenosis, It is divided into six aspects: the process of restenosis, bioactive substances and growth factors, smooth muscle cell proliferation and apoptosis, cell information transmission and transcription regulation, gene therapy of oncogenes and anti-cancer genes and restenosis, etc. Review.