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成纤维细胞生长因子的酸性分子和碱性分子均有促进血管平滑肌细胞分裂、增生的作用,对血管内皮细胞亦有丝裂源和趋化作用,并可在体内诱导毛细血管形成;它们在血管成形术后再狭窄过程中起着非常重要的作用。亦有报道极低剂量的酸性分子有抑制平滑肌细胞增生的作用,这样可能在防止血管成形术后再狭窄中发挥作用。
Both acidic and basic molecules of fibroblast growth factor promote the cell division and proliferation of vascular smooth muscle cells, also have mitosis and chemotaxis on vascular endothelial cells and induce capillary formation in vivo. Postoperative angioplasty restenosis plays a very important role. It has also been reported that extremely low doses of acidic molecules inhibit the proliferation of smooth muscle cells and thus may play a role in preventing restenosis after angioplasty.