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目的:研究免疫复方的药味配伍作用。方法:以H2O2造成血管内皮细胞损伤,采用析因设计方法,考察免疫复方药味配伍对血管内皮细胞损伤的保护作用。结果:当免疫复方的君药和佐使药固定为黄芪、丹参和牡丹皮时,与只用一味臣药相比,白花蛇舌草与小蓟合用,可明显增加血管内皮细胞损伤的保护作用。小蓟与仙鹤草合用,仙鹤草与白花蛇舌草合用,只表现为单独使用小蓟或白花蛇舌草对血管内皮细胞损伤的保护作用。结论:白花蛇舌草与小蓟有交互影响,具有协同保护血管内皮细胞损伤作用。小蓟与仙鹤草及白花蛇舌草与仙鹤草之间没有交互影响。
Objective: To study the compatibility of medicine and herbs of immune compound. Methods: The injury of vascular endothelial cells was induced by H2O2. The factorial design method was used to investigate the protective effect of the compound recipe of immune compound on vascular endothelial cell injury. Results: Compared with the Herba Astragalus, Radix Salviae Miltiorrhizae and Cortex Moutan, the combination of Hedyotis diffusa and Thistle could obviously increase the protective effect of vascular endothelial cell injury. Cirsium and Agrimony together, Agrimony and Hedyotis diffusa, only showed the use of thistle alone or Hedyotis diffusa on vascular endothelial cell injury. Conclusion: Hedyotis diffusa and Artemisia annua have interactive effects, with the protection of vascular endothelial cell injury. There was no interaction between thistle, Agrimony and Hedyotis diffusa and Agrimony.