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采用同种粗制内耳抗原（CIEAg）在已致敏的豚鼠内淋巴囊（ES）局部免疫，诱发出明显的前庭和听觉功能障碍，以及与Meniere病极为相似的内耳膜迷路水肿改变。从而证明ES局部同种内耳抗原免疫是一种有效的造成Meniere病的方法，揭示部分Meniere病的发病机制可能与自身免疫因素有关。
Local immunization with sensitized guinea pig endolymphatic sacs (ES) using the same crude inner ear antigen (CIEAg) evoked significant changes in vestibular and auditory dysfunction and edema of the inner ear membrane closely resembling Meniere’s disease. Therefore, it is demonstrated that the immunity of ES local topical inner ear antigen is an effective way to cause Meniere’s disease. It is suggested that the pathogenesis of some Meniere’s disease may be related to the autoimmune factors.