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对引起内淋巴水肿原因的探讨已经很多,自身免疫是新近才被认识的。文中回顾1981～1986年根据病人的临床表现、听力学资料和阳性的免疫学检查被诊断为自身免疫性内耳病的52例病人,其中27例表现为自身免疫性美尼尔氏综合征。所有这些病人淋巴细胞转化试验均阳性,临床表现为波动性听力减退、发作性眩晕或头晕、耳鸣或耳闷,并除外了听神经瘤,代谢性疾病或其它可能疾患。初诊时患者平均年龄为49岁(8～79岁),女性18例,男性9例;双侧者19例,单侧者8例;3例合并全身免疫性疾病。治疗包括:低盐饮食、利尿药、前庭抑制药和类固醇类药。细胞毒性药或血浆治疗仅用于对类固醇类药出现副作用的患者,
The cause of endolymphatic edema has been a lot of discussion, autoimmunity has only recently been recognized. In this paper, 52 patients diagnosed as autoimmune internal ear disease from 1981 to 1986 were retrospectively analyzed according to their clinical manifestations, audiology and positive immunological examinations. 27 of them showed autoimmune Meniere’s syndrome. All of these patients had a positive lymphocyte transformation test, with clinically apparent fluctuations in hearing loss, episodic dizziness or dizziness, tinnitus or ear irritation, with the exception of acoustic neuroma, metabolic disease or other possible disorders. The average age of patients at the time of first visit was 49 years (range, 8 to 79 years). There were 18 women and 9 males. Nineteen patients were bilateral and 8 were unilateral. Three patients had systemic autoimmune diseases. Treatments include: low-salt diet, diuretics, vestibule drugs and steroids. Cytotoxic drugs or plasma therapy is only used in patients with side effects of steroid drugs,