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目的观察单独应用孟鲁司特钠治疗成人咳嗽变异型哮喘的疗效。方法 29例成人咳嗽变异型哮喘患者给予孟鲁司特钠10 mg,每日1次,疗程4周,采用视觉模拟评分法判断治疗前、后咳嗽症状积分,并测定肺功能指标第1秒用力呼气容积(FEV1)、FEV1占预计值百分比(FEV1%pred)、呼气峰流速(PEF)。结果 29例患者治疗后咳嗽症状积分[(2.00±1.16)分],明显低于治疗前积分[(6.93±1.73)分,P<0.01]。治疗前、后肺功能指标FEV1[(2.70±0.49)L vs(2.97±0.55)L],FEV1%pred[(79.34±10.32)%vs(87.03±9.63)%],PEF[(5.59±1.22)L vs(6.43±1.37)L]比较差异均有统计学意义(P均<0.05),治疗后肺功能明显改善。结论单独使用孟鲁司特钠治疗成人咳嗽变异型哮喘可以有效减轻咳嗽症状、改善肺功能。
Objective To observe the curative effect of montelukast sodium alone on adult cough variant asthma. Methods Twenty-nine adult patients with cough variant asthma were given montelukast sodium 10 mg once daily for 4 weeks. The scores of cough before and after treatment were evaluated by visual analogue scale and the first second force of lung function was measured Expiratory volume (FEV1), FEV1% predicted (FEV1% pred), and peak expiratory flow (PEF). Results The scores of cough in 29 patients [(2.00 ± 1.16) points] were significantly lower than those before treatment [(6.93 ± 1.73) points, P <0.01]. FEV1% pred [(79.34 ± 10.32)% vs (87.03 ± 9.63)%] and PEF [(5.59 ± 1.22) L vs (2.97 ± 0.55) L] before and after treatment, L vs (6.43 ± 1.37) L, respectively (all P <0.05). The lung function was improved significantly after treatment. Conclusion Montelukast alone treatment of adult cough variant asthma can effectively reduce cough symptoms and improve lung function.