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溃疡性结肠炎的活动性习用Truelove及Witts提出的标准进行估计,但它难于准确而客观地监测炎症本身的变化。肠粘膜活检组织学观察需要取材较多和细胞计数技术,且重复结肠镜检查和多处活检对重症患者不无危险。定量检测从发炎肠道逸出的白细胞是一个可供选择的方法。鉴于~(111)铟可紧密地标记在白细胞上,标记白细胞可迅速游走至发炎的肠道,进入肠腔而随粪便排出体外,定量测定粪便的放射活性可表示粪便白细胞的排出量。作者等测定了29例溃疡性结肠炎患者39次粪便内~(111)铟标记白细胞排泄量,并与临床和实验室估测的活动性进行前瞻性比较,另以25例结肠易激综合征(IBS)患者作为对照。在了解粪便~(111)铟测定结果之
The activity of ulcerative colitis is estimated using the criteria proposed by Truelove and Witts, but it is difficult to accurately and objectively monitor changes in the inflammation itself. Intestinal mucosal biopsy histological observation needs more material and cell counting techniques, and repeated colonoscopy and multiple biopsies in critically ill patients are not without danger. Quantitative detection of leukocytes released from the inflamed intestine is an option. Since ~ (111) indium can be tightly labeled on leukocytes, labeled leukocytes can rapidly migrate to the inflamed intestine and enter the intestine and excreted with the excrement. Quantitative determination of fecal radioactivity indicates the excretion of leucocytes. The authors determined 39 intranasal (111) indium-labeled leukocyte excretion in 29 patients with ulcerative colitis and prospectively compared with the clinical and laboratory estimates of activity, and another 25 patients with irritable bowel syndrome (IBS) patients as controls. In understanding the ~ (111) indium assay results