着色真菌病是一种较少见而又难治的慢性进行性深部真菌病。现将我们最近遇到的一例报告如下。病例摘要曾××,男,70岁,湖南籍,农民。右膝关节长结节,痒22年。初在右膝关节伸侧长黄豆至樱桃大暗红色柔软之结节,自行破溃,常流出脓血,溃疡长久不愈。愈后结疤痕,且在其上结银白色鳞痂。常长小脓疱,有痒感。皮损渐扩大至整个膝关节伸面。1962年某医院诊断为“牛皮癣”,治疗三月无效,后又按“斑状皮肤结核”治疗一年余,仍未见效。1978年取皮损活检,报告为“硬皮病”,未予治疗。此后皮损迅速蔓延至膝关节上方,但无全身症状,1983年2月来我院就诊。检查:一般情况尚可。右膝关节因皮损疤痕挛缩,活动稍变限,轻微跛行。无病理反射征,右膝关节伸侧至大腿下段有18×13cm暗红色斑块状疤痕,边缘清楚整齐,中央部位附有浅黄色湿润痂皮, Fungal fungal disease is a rare and refractory chronic progressive mycosis. Now we have encountered a recent report is as follows. Case summary Have × ×, male, 70 years old, Hunan, peasants. Right knee nodules, itchy for 22 years. Beginning in the right knee extensor long soybeans to cherry dark red soft nodules, rupture their own, often out of sepsis, ulcers long unhealed. The more you knot a scar, and a silver callus on it. Often small pustules, itching. Skin lesions gradually widened to the knee extension surface. A hospital in 1962 diagnosed as “psoriasis”, treatment of three months invalid, then press “spotted skin tuberculosis” more than a year of treatment, still not effective. In 1978 to take the lesion biopsy, reported as “scleroderma”, untreated. Since then the rapid spread of skin lesions to the top of the knee, but no systemic symptoms, in February 1983 to our hospital. Check: the general situation is acceptable. The right knee joint contracture due to skin lesions, activity slightly changed limit, a slight limp. No pathological reflex sign, the right knee joint extensor to the lower thigh 18 × 13cm dark red plaque scar, the edge of clear and neat, the central part attached to the light yellow moist crust,