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观察了４０例慢性肾衰（ＣＲＦ）病人淋巴细胞增殖反应与白介素２／白介素２受体（ＩＬ－２／ＩＬ－２Ｒ）系统之间的关系。结果表明：（１）ＣＲＦ病人淋巴细胞在体外培养时，ＩＬ－２产生水平以及对丝裂素原和抗原刺激的增殖反应明显低于正常组，培养上清ＩＬ－２水平与淋巴细胞转化率呈正相关。外源性，ＩＬ－２可明显增强ＣＲＦ及正常组的淋巴细胞增殖反应，但前者的增幅明显高于正常对照。（２）ＣＲＦ组淋巴细胞表面ＩＬ－２Ｒ的自发表达及血浆和淋巴细胞培养上清中ＳＩＬ－２Ｒ水平均较正常明显增高，血浆ｓＩＬ－２Ｒ与血浆肌酐水平呈正相关。在维持性血透病人，血浆ｓＩＬ－２Ｒ并与透析时间有关。由此表明，ＣＲＦ时的淋巴细胞增殖反应缺陷与ＩＬ－２水平低下有关，而后者可能是因淋巴细胞生成减少以及淋巴细胞预激活而致ＩＬ－２吸收增加所致。
The relationship between lymphocyte proliferation and interleukin 2 / interleukin 2 receptor (IL-2 / IL-2R) system in 40 patients with chronic renal failure (CRF) was observed. The results showed that: (1) IL-2 production and lymphocyte proliferation in CRF patients were significantly lower than that in normal group when cultured in vitro. The level of IL-2 in the culture supernatant and lymphocyte transformation rate Was positively correlated. Exogenous, IL-2 can significantly enhance the CRF and normal group lymphocyte proliferation, but the former increased significantly higher than the normal control. (2) The spontaneous expression of IL-2R on the surface of lymphocytes in CRF group and the level of SIL-2R in plasma and lymphocyte culture supernatant were significantly higher than those of normal group. The level of plasma sIL-2R was positively correlated with plasma creatinine. In maintenance hemodialysis patients, plasma sIL-2R and dialysis time. Thus, CRF defects in lymphocyte proliferation response and low levels of IL-2, which may be due to decreased production of lymphocytes and pre-activation of lymphocytes caused by increased IL-2 absorption.