论文部分内容阅读
[目的]探讨NSCLC组织中EGFR的表达特点及其与临床特征的关系。[方法]82例NSCLC石蜡标本,男性53例,女性29例;鳞癌39例,腺癌43例。采用免疫组化S-P法检测NSCLC中EGFR的表达。[结果]EGFR在NSCLC中的表达明显高于对照组(P<0.01)。EGFR阳性表达与临床分期及淋巴结转移密切相关(P<0.01),与患者的年龄、性别、吸烟状况、病理类型、组织分化无关。[结论]EGFR在NSCLC中高表达,其高表达可能促进肿瘤细胞的侵袭、转移。
[Objective] To investigate the expression of EGFR in NSCLC and its relationship with clinical features. [Methods] 82 cases of NSCLC paraffin specimens, 53 males and 29 females; squamous cell carcinoma in 39 cases, adenocarcinoma in 43 cases. The expression of EGFR in NSCLC was detected by immunohistochemical S-P method. [Results] The expression of EGFR in NSCLC was significantly higher than that in control group (P <0.01). The positive expression of EGFR was closely related to clinical stage and lymph node metastasis (P <0.01), but not with age, gender, smoking status, pathological type and differentiation. [Conclusion] EGFR is highly expressed in NSCLC, and its high expression may promote the invasion and metastasis of tumor cells.