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目的:探讨去甲万古霉素对耐甲氧西林葡萄球菌感染的治疗效果和合理使用。方法:调查我院2007年1-12月住院部各科使用去甲万古霉素者54例,统计、分析基础疾病、细菌学培养结果及药敏试验结果。按《医院感染管理学》标准评价用药合理性。结果:痊愈26例,显效19例,进步3例,无效4例,死亡2例,有效率为81.5%。出现药物不良反应者11例,用药合理者和基本合理者占83.4%,不合理者16.6%。结论:去甲万古霉素对耐甲氧西林葡萄球菌感染的治疗有效,应限制合理使用,使其长期保持对该菌感染的有效性。
Objective: To investigate the therapeutic effect and rational use of norvancomycin against methicillin-resistant staphylococcal infection. Methods: From January to December 2007, 54 inpatients with in-vancomycin in our department were investigated. Statistics and analysis of basic diseases, bacteriological culture results and drug susceptibility test results were performed. According to “hospital infection management” standard evaluation of drug rationality. Results: 26 cases were cured, 19 cases were markedly improved, 3 cases were improved, 4 cases were ineffective and 2 cases died. The effective rate was 81.5%. There were 11 cases of adverse drug reactions, accounting for 83.4% of patients with reasonable and basic reasonable, 16.6% of unreasonable. Conclusion: Norvancomycin is effective in the treatment of methicillin-resistant staphylococcal infection, so it should be rationally used and its validity should be maintained for a long time.