例1 女,57岁。5年前出现周围神经炎、脑脊液蛋白升高、低三碘甲腺原氨酸综合征、子宫肌瘤,伴全身肤色变黑。4年前出现双下肢水肿、腹水、肝脾肿大、肾上腺及甲状腺功能减低。半年前发现糖尿病。10d前出现阵发性全身骨痛。体检：乳头、脐周、颜面色素沉着：双下肺可及少量湿啰音。腹膨隆,移动性浊音阳性。肝脏肋下3cm。双下肢高度凹陷性浮 Example 1 Female, 57 years old. 5 years ago appeared peripheral neuritis, cerebrospinal fluid protein, low triiodothyronine syndrome, uterine fibroids, with the whole body dark complexion. Four years ago, there were bilateral lower extremity edema, ascites, hepatosplenomegaly, and adrenal and thyroid dysfunction. Six months ago found that diabetes. 10d before the emergence of paroxysmal body pain. Physical examination: nipple, umbilical week, face pigmentation: Double lower lungs and a small amount of wet rales. Abdominal bulging, shifting dullness positive. Liver ribs 3cm. Depression of the lower limbs float