中脑导水管周围灰质（ＰＡＧ）又称中脑中央灰质，近三十年来人们逐渐认识到它是一个结构与功能都非常复杂的区域。它广泛参与镇痛、心血管反应等过程的中枢调节，在伤害抑制和应激行为的整合等方面起着枢纽作用。本文总结了近七十年来关于大鼠中脑导水管周围灰质细胞构筑及纤维联系的文献，为进一步研究此区提供形态学基础资料。 Periaqueductal gray matter (PAG), also known as central mesencephalic gray matter, has been recognized for nearly three decades as an area of ​​very complex structure and function. It is widely involved in the central regulation of pain relief, cardiovascular response and other processes, and plays a pivotal role in the integration of injury suppression and stress behavior. This article summarizes the literature about the construction of the gray matter cells around the midbrain periaqueductal gray in the past seventy years and provides the basis for the further study of this area.