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酮康唑(商品名里素劳)是近代口服强力抗真菌药物之一,治疗浅部真菌病及某些深部真菌病有很好的临床疗效。如何发挥其疗效,减少不良反应,特别是避免其发生肝脏损害,是临床使用该药的一个重要课题。现将我们应用此药治疗下列疾病的经验进行介绍。 1 头癣小儿口服量一般为4～6 mg/(kg·d),最大量可达到5～10 mg/(kg·d),疗程为21～28d。一般认为疗效与灰黄霉素相似,也有人认为效果较差。北京市的一些医疗单位认为效果差,是因为北京市头癣病原菌大多为羊毛小孢子菌。据文献记载,酮康唑对羊毛小孢子菌引起的头癣疗效仅为29％,而毛癣菌引起的头癣则为73％。我们的经验是,对羊毛小孢子菌引起
Ketoconazole (trade name in labor) is one of the modern oral anti-fungal drugs, the treatment of superficial mycosis and some deep fungal disease has a good clinical effect. How to play its efficacy and reduce adverse reactions, especially to avoid its occurrence of liver damage, is an important issue for clinical use of the drug. Now we apply this medicine to treat the following diseases experience introduction. Tinea pedis 1 oral dose is generally 4 ~ 6 mg / (kg · d), the maximum amount of up to 5 ~ 10 mg / (kg · d), treatment for 21 ~ 28d. It is generally believed that the efficacy and griseofulvin similar, others think the effect is poor. Some medical institutions in Beijing think the result is poor because most of the pathogenic bacteria in Beijing are ringworm microsporum. According to the literature, the effect of ketoconazole on tinea capitis caused by Microsporum sp. Was only 29%, while that of Trichophyton mentagrophytes was 73%. Our experience is that caused by the microsporum of wool