结核病灶发生凝固性坏死时,使细胞失去轮廓而形成一种乳酪样团块,称为干酪性病灶。干酪性病灶软化是成人结核的主要病变,其机制目前尚处于研究探讨阶段。众所周知纤维蛋白和纤维蛋白原是纤溶酶的作用底物,纤溶酶和纤维蛋白原一起在炎症渗出物中移动,而且总是存在于纤维蛋白中,受刺激的巨噬细胞可分泌纤溶酶原激活剂,后者和许多其它的激活剂可使纤溶酶原转化为纤溶酶,从而引起邻近的纤维蛋白溶解。但在干酪灶中的纤维蛋白可能不被溶解,因为结核结节中的细胞已死亡,不能产生纤 Tuberculous lesions occur when coagulation, the loss of the outline of cells and the formation of a cheese-like clumps, known as the cheese lesions. Chest soft lesions of the main lesions of adult tuberculosis, the mechanism is still in the research stage. It is well-known that fibrin and fibrinogen are the substrates of plasmin. Plasmin and fibrinogen move together in inflammatory exudates and are always present in fibrin. Stimulated macrophages secrete fibrinolytic The zymogen activator, the latter, and many other activators convert plasminogen to plasmin, causing the adjacent fibrin to dissolve. However, fibrin in cheese foci may not be dissolved because the cells in tuberculous nodules have died and can not produce fiber