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利用细胞内Ｃａ２＋浓度测定技术，直接测定了牙髓神经纤维内Ｃａ２＋浓度，结果发现：无论是临床炎症性痛过敏牙髓，或是炎症介质组织胺、５－羟色胺处理的牙髓，其神经纤维内Ｃａ２＋浓度均比正常牙髓显著升高。而当降低细胞外液Ｃａ２＋浓度时，虽经炎症介质处理，神经纤维内Ｃａ２＋浓度与正常组无显著差异。说明牙髓神经纤维内Ｃａ２＋升高可能与其炎性痛过敏的发生有关。增加的Ｃａ２＋可能来源于细胞外液的Ｃａ２＋跨膜通道内流
Using intracellular Ca2 + concentration measurement technology, direct determination of the concentration of Ca2 + in the pulp nerve fibers, the results found that: either clinical inflammatory pain hyperalgesia pulp, or inflammatory mediators of histamine, serotonin treated pulp, the nerve fibers Intracellular Ca2 + concentrations were significantly higher than normal pulp. However, when the extracellular Ca2 + concentration was decreased, the Ca2 + concentration in the nerve fibers was not significantly different from that in the normal group, though treated by inflammatory mediators. It is concluded that elevated Ca2 + in pulp nerve fibers may be related to the occurrence of inflammatory pain hypersensitivity. Increased Ca2 + may originate from extracellular Ca2 + transmembrane channel influx