癫痫是一类常见的大脑机能失调性疾病 ,大脑神经元细胞兴奋和抑制之间的失衡是癫痫发作最根本的原因。中枢组胺作为神经递质和神经调质影响杏仁核“点燃性”癫痫的发作和预后。本文介绍了中枢组胺能神经系统的概况并概述国内外最新的关于中枢组胺抗癫痫作用的研究状况以及组胺能抗癫痫药物在临床应用上的前景和展望 Epilepsy is a common type of brain dysfunction. The imbalance between the excitability and depression of neuronal cells in the brain is the most fundamental cause of seizures. Central histamine as a neurotransmitter and neuromodulator affect the onset of amygdala “flare” epilepsy and prognosis. This article introduces the overview of central histamine nervous system and summarizes the latest research on central antihistaminic epilepsy and the prospect and prospect of histamine antiepileptic drugs in clinical application