As2 O3 可有效地治疗 APL患者 ,尤其是维甲酸治疗后复发的病例。但近来研究发现其治疗后出现了诸如肝损伤、心功能失常以及类似于维甲酸中毒症状的严重副作用 ,因此有必要寻找一种新的更安全的 As2 O3 用药方法。为此 ,作者探讨了联合应用 As2 O3 和 GM-CSF治疗 APL的体内及体 As2 O3 is effective in the treatment of APL patients, especially in the case of retinoic acid recurrence after treatment. However, recent studies have found that serious side effects such as liver damage, cardiac dysfunction, and symptoms similar to retinoic acid have occurred after the treatment. Therefore, it is necessary to find a new and safer As2 O3 administration method. To this end, the authors explored the combination of As2 O3 and GM-CSF for the treatment of APL in vivo and in vivo