作者报告3例严重而抗治疗的结节病,用小剂量氨甲喋呤(MTX)治疗,均获显著效果,以面部肉芽肿和溃疡效果最好.治疗效果出现在治疗数周后,但达到最佳疗效需6～9个月.3例患者皮肤活组织检查均有结节病性内芽肿表现,除肺部外无其它内脏器官受累的临床表现.治疗方法与常用 The authors reported 3 severe and resistant sarcoidosis patients treated with low-dose methotrexate (MTX), both of which were shown to have the best effect with the best effect of facial granuloma and ulcer. The therapeutic effect appeared best after several weeks of treatment Efficacy of 6 to 9 months .3 patients with skin biopsy have intranodal sodustic myxoedema performance, except for the lungs without other clinical manifestations of involvement of internal organs. Treatment methods and commonly used