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以产妇住址与某石油化工厂距离为暴露指标，以先天畸形、死胎、出生低体重和早产等不良妊娠结局为效应指标，采用病例对照研究方法探讨石油化工企业污染与不良妊娠结局的关系。经多项分类Ｌｏｇｉｓｔｉｃ回归模型分析，结果发现：控制某些混杂因素作用后，距离与发病的显著性联系；且相对危险性随距离的增大而逐渐降低。居住在３ｋｍ以内者发生先天畸形、死胎和出生低体重的危险性增加，而与早产发生无关。提示石油化工企业污染可能是其周围居民发生不良妊娠结局的危险因素之一。
Taking the distance between maternal address and a petrochemical factory as the exposure index, taking the adverse pregnancy outcomes such as congenital malformations, stillbirths, low birth weight and premature birth as the effect indexes, a case-control study was conducted to explore the relationship between petrochemical enterprise pollution and adverse pregnancy outcomes. Logistic regression analysis showed that there was a significant relationship between distance and onset of disease after controlling for some confounding factors, and the relative risk decreased gradually with distance increasing. People living within 3km congenital malformations, stillbirth and low birth weight increased risk, but not with the occurrence of preterm birth. It is suggested that the pollution of petrochemical enterprises may be one of the risk factors of adverse pregnancy outcomes in the residents around them.