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430名被胃镜证实为十二指肠疡溃病患者,接受了一年以下至八年以上疗程的雷尼替丁维持治疗。对这些患者,我们进行了非对照性临床研究。这些病人以前均未行过治疗性手术。我们每六个月进行一次常规评价。在症状复发时行胃镜检查。疡溃复发时给予四至八周全剂量治疗,随后用同剂量或稍大剂量抗疡溃药维持治疗。按临床要求,在观察期间,一些患者的维持剂量根据症状和其它临床标准进行调整。这包括其些阶段不维持治疗的可能。
430 patients confirmed by gastroscopy duodenal ulcer patients, received less than one year to eight years of treatment with ranitidine maintenance therapy. For these patients, we conducted a non-controlled clinical study. None of these patients had previously undergone curative surgery. We conduct a regular evaluation every six months. Gastroscopy is performed when symptoms recur. Ulcer ulcer recurrence given four to eight weeks of full-dose treatment, followed by the same dose or slightly larger ulcer ulcer maintenance treatment. According to clinical requirements, the maintenance dose for some patients was adjusted for symptoms and other clinical criteria during the observation period. This includes the possibility that some stages do not sustain treatment.