Li等(1984)用甲氟喹、青蒿素及乙胺嘧啶-周效磺胺(法西达)治疗急性恶性疟患者的实验资料提示,用单一青蒿素治疗,对清除疟原虫所需的时间最短(44.7小时),最有效。但鉴于该药的再燃率高,所以不予考虑单独使用。Peto等对Li等的这一评论持有异议。他们认为青蒿素的用药时间太短,只有3日,尽管其血浆半衰期为数小时,而其他 Experimental data from Li et al. (1984) for treatment of acute falciparum malaria with mefloquine, artemisinin, and pyrimethamine-fcytidine suggest that treatment with single artemisinin The shortest time (44.7 hours), the most effective. However, given the high rebound rate of the drug, it is not considered for use alone. Peto et al. Disagreed with Li et al.’s comment. They think the artemisinin medication is too short for only 3 days despite its plasma half-life of hours, while others