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前列环素(PGl_2)具有强烈的抑制血小板聚集和扩张血管作用,而血栓素A_2(TXA_2)的作WT用刚好相反,二者之间平衡失调导致血小板与血管壁相互作用异常,这在动脉粥样硬化和冠心病的发生发展过程中起着重要作用。因此抗血小板治疗在冠心病防治中有重要的意义。阿司匹林(ASA)被广泛用于抗血小板治疗,但其合理剂量尚有争议。中国医学科学院阜外医院观察的结果如下:
Prostacyclin (PGl_2) has a strong inhibition of platelet aggregation and dilation of blood vessels, and thromboxane A_2 (TXA_2) for the opposite of WT, the imbalance between the two lead to platelet-vessel wall abnormalities, which in atheroma Such as sclerosis and coronary heart disease play an important role in the development process. Therefore, anti-platelet therapy in the prevention and treatment of coronary heart disease is of great significance. Aspirin (ASA) is widely used in antiplatelet therapy, but its reasonable dosage is controversial. Fu Wai Hospital, Chinese Academy of Medical Sciences observed the following results: