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睾酮与孕酮配伍是有希望的可逆性男性避孕方案。最近的一项研究采用国产长效十一酸睾酮注射液 (2 5 0mg/mon)与国产长效左旋炔诺孕酮硅胶棒 (15 0mg)配伍 ,只造成约 40 %的受试者达到无精子。该研究在两名志愿者身上试用同样的配伍 ,但剂量均加倍 (睾酮 5 0 0mg/ 5wk ,左旋炔诺酮 30 0mg) ,结果维持了血清睾酮水平 ,抑制了血清促性腺激素LH和FSH ,两名受试者均达到无精子 ,且停药后精子数和促性腺激素水平恢复。因此推测这种配伍这种剂量是中国有希望的男性避孕方案 ,值得较大范围的进一步临床研究。
Testosterone compatibility with progesterone is a promising reversible male contraceptive solution. A recent study using domestic long-acting testosterone undecanoate injection (250 mg / mon) and homemade long-acting levonorgestrel gel stick (15 0mg) only caused about 40% of the subjects reached no sperm. The study tested the same compatibility in two volunteers but doubles the dose (testosterone 500 mg / 5 wk and levonorgestrel 30 0 mg), maintaining serum testosterone levels, inhibiting serum gonadotropin LH and FSH, Both subjects achieved azoospermia, and sperm count and gonadotropin levels recovered after withdrawal. Therefore, it is speculated that this compatibility of this dose is a promising male contraceptive program in China and deserves a broader scope for further clinical studies.