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目的:探讨2型糖尿病患者采用盐酸二甲双胍片与格列美脲分散片联合治疗的临床效果。方法:选择佛山市顺德区大良社区卫生服务中心2015年6月至2016年6月期间收治的2型糖尿病患者60例为研究对象,随机分为两组,其中对照组行常规治疗,而观察组则运用盐酸二甲双胍片与格列美脲分散片联合治疗,对两组的治疗效果进行对比分析。结果:治疗前,两组的空腹血糖(FBG)、餐后2 h血糖(2 hPPG)比较,差异均无统计学意义(P>0.05);治疗后,相比较对照组而言,观察组的2 hPPG、FBG水平明显下降,组间对比,差异具有统计学意义(P<0.05);与对照组相比,观察组的治疗有效率高,组间对比,差异具有统计学意义(P<0.05);同时,观察组不良反应发生率低于对照组,差异具有统计学意义(P<0.05)。结论:临床上给予2型糖尿病患者盐酸二甲双胍与格列美脲分散片联合治疗,能够降低血糖,还不容易发生不良反应,具有较高的安全性。
Objective: To investigate the clinical effect of combined treatment of metformin hydrochloride tablets and glimepiride dispersible tablets in type 2 diabetic patients. Methods: Sixty patients with type 2 diabetes who were treated in Daliang Community Health Service Center of Shunde District of Foshan City from June 2015 to June 2016 were selected and randomly divided into two groups, of which the control group received routine treatment and the observation group The use of metformin hydrochloride tablets and glimepiride dispersible tablets combined treatment of the two groups were compared the therapeutic effect. Results: Before treatment, the fasting blood glucose (FBG) and 2 h postprandial blood glucose (2 h PPG) in the two groups had no significant difference (P> 0.05); after treatment, compared with the control group, (P <0.05). Compared with the control group, the treatment group had a higher effective rate of treatment and the difference between the two groups was statistically significant (P <0.05) ); Meanwhile, the incidence of adverse reactions in the observation group was lower than that of the control group, the difference was statistically significant (P <0.05). Conclusion: The combination therapy of metformin hydrochloride and glimepiride dispersible tablets in patients with type 2 diabetes mellitus can reduce blood sugar, and is not prone to adverse reactions, with high safety.