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富亮氨酸重复序列(leucine-rich repeat,LRR)是一种常见的蛋白质结构域.含有富亮氨酸重复序列的蛋白质简称LRR蛋白.LRR蛋白在真核生物和原核生物的细胞和组织中广泛分布,其定位的特异性以及与之相互作用蛋白质的复杂性,决定了LRR蛋白功能的多样性.许多LRR蛋白相对特异性表达于神经系统,绝大多数在神经系统中高表达的LRR蛋白属于跨膜蛋白,它们主要作为细胞黏附分子或配体结合蛋白参与突触的形成、神经突起的生长发育、神经递质的转移和释放等神经系统正常生理活动.LRR蛋白的异常表达将会导致神经、精神系统疾病的发生.
A leucine-rich repeat (LRR) is a common protein domain, which contains a leucine-rich repeat protein called LRR protein, which is expressed in cells and tissues of eukaryotes and prokaryotes Widely distributed, the specificity of its localization and the complexity of the proteins interacting with it determine the diversity of LRR proteins.Many LRR proteins are relatively specific expressed in the nervous system, and the vast majority of LRR proteins highly expressed in the nervous system belong to They are involved in the formation of synapses, the growth and development of neurites, the transfer and release of neurotransmitters, and other normal physiological activities of the nervous system, mainly as cell adhesion molecules or ligand-binding proteins. Abnormal expression of LRR proteins will lead to nerve , The occurrence of mental illness.