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CD_9抗原是血小板膜蛋白的主要组份之一,在每个人血小板表面约含4 000个CD_9抗原,虽然它在血小板功能方面的作用尚不明确,但由于它可与活化的血小板中GPⅡb/Ⅲa相联结,从而对血小板的聚集功能起调控作用。自1983年率先发现血小板强致聚剂P24单抗(ALB_6)以来,文献中陆续报道了十几个可引起血小板聚集的CD_9单抗,并对其激活机制进行了多方面的研究,本文对此作一综述。 1 CD_9抗原(P_(24))的初级结构及生化特点 CD_9抗原做为一种广泛分布于多种细胞表面的膜蛋白,首先是用单抗BA_2在白血病及淋巴细胞表面确定的。其分布的广泛性提示其作用的重要性及多样性。它是一分子量为24 000道尔顿的单链多肽,等电点为7.3,分子内部无二硫键联结,与其它多
CD_9 antigen is one of the main components of platelet membrane protein. About 4 000 CD_9 antigens on the surface of each human platelet, although its role in platelet function is not clear, but because it can activate platelet GP Ⅱ b / Ⅲ a Linked to the platelet aggregation function play a regulatory role. Since the first discovery of the platelet potent polymerization inhibitor P24 monoclonal antibody (ALB6) in 1983, more than a dozen CD9 mAbs that can cause platelet aggregation have been reported in the literature and various aspects of its activation mechanism have been studied. In this paper, Make a review Primary structure and biochemical characteristics of CD_9 antigen (P_ (24)) CD_9 antigen is a membrane protein widely distributed on various cell surfaces. It is firstly identified on the surface of leukemia and lymphocytes by monoclonal antibody BA_2. The widespread nature of its distribution suggests the importance and diversity of its role. It is a single chain polypeptide with a molecular weight of 24 000 daltons and has an isoelectric point of 7.3 with no intramolecular disulfide bond,