论文部分内容阅读
五氯酚(pcp)是广泛用于木材防腐的一种杀菌剂。在急性pcp中毒时伴有氧化磷酸化的解偶联。作者选用恒河猴(雌雄各三只)为实验对象,以剂量为10mg/kg的~(14)C pcp玉米油一剂口服,投药后360小时内,以一定的时间间隔分别测定血浆和尿中的pcp浓度。最后一次采样后,用过量之苯巴比妥作腹腔注射分别处死雌、雄猴各二只。取出以下组织作~(14)C活性测定:肾上腺、脑、胆囊、大肠、小肠、肾、肝、肺、卵巢、胰、脾、胃、睾丸、膀胱、子宫、
Pentachlorophenol (pcp) is a bactericide widely used in wood preservatives. In acute PCp poisoning accompanied by oxidative phosphorylation uncoupling. The author chose Rhesus macaque (three males and three females) as the experimental subjects, taking a dose of ~ (14) C pcp corn oil at a dose of 10 mg / kg orally. Within 360 hours after administration, blood plasma and urine were measured at certain time intervals In the pcp concentration. After the last sampling, an excess of phenobarbital was injected intraperitoneally for each of the two female and male monkeys. The following tissues were removed for ~ (14) C activity determination: adrenal, brain, gallbladder, large intestine, small intestine, kidney, liver, lung, ovary, pancreas, spleen, stomach, testis, bladder,