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采用ＨＰＬＣ法研究醋氯芬酸在大鼠体内的药代动力学。醋氯芬酸在大鼠体内的吸收较为迅速，给药后约１０ｍｉｎ达到血药浓度峰值，其药－时曲线符合一级吸收的二室模型，分布半衰期仅为４ｍｉｎ左右，消除半衰期约为５０ｍｉｎ。三种剂量下的ＡＵＣ分别为４２．１、９０．３、１８１．８μｇｍｉｎ／ｍｌ，剂量与ＡＵＣ具有良好的线性关系，提示醋氯芬酸在大鼠体内的处置属于线性动力学，其动力学参数呈剂量非依赖性。大鼠按１０ｍｇ／ｋｇ剂量灌服醋氯芬酸后，心、胃、肠和肌肉组织内的浓度较高。醋氯芬酸在大鼠粪、尿和胆汁中的排泄较少。大鼠按１０ｍｇ／ｋｇ剂量灌服醋氯芬酸后，其２４ｈ内累积尿排泄百分率仅为０．０９０％±０．０１８％；其２４ｈ内累积粪便排泄百分率仅为０．２２％±０．０７％；其１２ｈ内累积胆汁排泄百分率仅为０．３３％±０．０９％。
Pharmacokinetics of aceclofenac in rats was studied by HPLC. Aceclofenac absorption in rats more rapidly, about 10min after administration to reach the plasma concentration peak, the drug-time curve in line with the absorption of a two-compartment model, the distribution of half-life of only about 4min, elimination half-life of about 50min . The AUC of the three doses were 42.1, 90.3 and 181.8μgmin / ml, respectively. The dose and AUC had a good linear relationship, suggesting that the treatment of aceclofenac in rats was linear and its kinetics The parameters were dose-independent. Rats fed 10 mg / kg aceclofenac at higher concentrations in heart, stomach, intestine and muscle. Aceclofenac excretes less in feces, urine and bile in rats. Rats fed 10mg / kg dose of aceclofenac, 24h cumulative urinary excretion rate was only 0.090% ± 0.018%; 24h cumulative excretion rate was only 0.22% ± 0.%. 07%; within 12h cumulative bile excretion percentage was only 0.33% ± 0.09%.