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目的探讨缬沙坦联合银杏达莫注射液治疗早期糖尿病肾病(DN)患者的临床效果。方法选取2012年5月至2013年6月医院收治的早期DN患者资料85例,按随机数字表法将其分为观察组(43例)和对照组(42例)。对照组患者给予缬沙坦治疗,观察组患者在其基础上给予银杏达莫注射液,比较两组患者的临床疗效。结果观察组患者总有效率为90.7%,明显高于对照组的73.8%,差异有统计学意义(P<0.05);观察组患者UAER、血清肌酐、血尿素氮均明显低于对照组,差异均有统计学意义(均P<0.05)。结论缬沙坦联合银杏达莫注射液治疗早期DN临床效果明显,能明显降低尿蛋白的排泄率,改善肾功能。
Objective To investigate the clinical effect of valsartan combined with ginkgo dipyridamole injection in the treatment of patients with early diabetic nephropathy (DN). Methods Eighty-five patients with early DN admitted to our hospital from May 2012 to June 2013 were divided into observation group (n = 43) and control group (n = 42) according to random number table. Patients in the control group were treated with valsartan. Patients in the observation group were given ginkgo dipyridamole injection on the basis of their clinical efficacy. Results The total effective rate in the observation group was 90.7%, which was significantly higher than that in the control group (73.8%, P <0.05). The UAER, serum creatinine and blood urea nitrogen in the observation group were significantly lower than those in the control group All were statistically significant (P <0.05). Conclusion Valsartan combined with ginkgo dipyridolum injection in the treatment of early DN has obvious clinical effect, can significantly reduce the urinary protein excretion rate, improve renal function.