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目的:研究复方丹参片联合维生素E对血吸虫肝纤维化的影响。方法:将我院1998~2004年来自血吸虫疫区的血吸虫肝纤维化患者46例,随机分为对照组23例,仅给予保肝药;治疗组23例,在对照组的基础上加用复方丹参片及维生素E,疗程6个月。比较两组治疗前后ALT、AST及血清前胶原III(PIIIP)、胶原IV(IV-C)、层连蛋白(LN)、透明质酸酶(HA)水平。分析疗程结束时两组肝纤维化变化情况。结果:两组ALT、AST均较治疗前有明显好转(P<0.05)。治疗组PIIIPI、V-C、HA水平较治疗前显著降低(P<0.05),LN无明显变化。对照组PIIIP、IV-C、HA、LN水平与治疗前相比则无显著的统计学意义。治疗组纤维化积分较治疗前有明显的下降(P<0.05),而对照组无显著性改变。结论:复方丹参片联合维生素E对血吸虫肝纤维化的发展有一定的阻断作用,此疗法具有价格便宜、疗效较好、无明显的副反应的特点,值得在农村推广应用。
Objective: To study the effect of Fufang Danshen Tablets combined with vitamin E on liver fibrosis of schistosomiasis. Methods: Forty-six patients with schistosomiasis hepatic fibrosis from schistosomiasis in our hospital from 1998 to 2004 were randomly divided into control group (n = 23) and hepatoprotective drug alone (n = 23). On the basis of the control group, Danshen tablets and vitamin E, treatment for 6 months. The levels of ALT, AST and serum levels of PIIIP, IV-C, LN and HA were compared before and after treatment. Analysis of the end of the two groups of liver fibrosis changes. Results: ALT and AST in both groups were significantly improved compared with those before treatment (P <0.05). The levels of PIIIPI, V-C and HA in the treatment group were significantly lower than those before treatment (P <0.05), but LN did not change significantly. The levels of PIIIP, IV-C, HA and LN in the control group were not significantly different from those before treatment. The fibrosis scores of the treatment group decreased significantly (P <0.05) compared with those before treatment, but there was no significant difference in the control group. CONCLUSION: Compound Danshen Tablets combined with Vitamin E can block the development of schistosomiasis hepatic fibrosis. The therapy has the characteristics of cheap price, good curative effect and no obvious side effects. It is worth popularizing and applying in rural areas.