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目的:观察灯盏花素对小鼠乳腺癌手术切除后转移和复发的影响。方法:将小鼠4 T1乳腺癌细胞植入雌性BALB/c小鼠乳房脂肪垫下。乳腺癌直径达10 mm时手术切除,次日治疗开始,包括灯盏花素治疗、阿霉素化疗及放射治疗。治疗效果通过小鼠术后转移和复发率、小鼠血清干扰素λ(IFN-λ)和白细胞介素2(IL-2)、及小鼠存活时间评价。结果:对照组、阿霉素化疗组、放射治疗和灯盏花素组乳腺癌复发率分别为50%、100%、100%和20%;肺内出现转移灶率分别为70%、100%、100%和20%。与对照组比较,阿霉素化疗组和放射治疗组小鼠有明显较低的血清IFN-λ和IL-2,而灯盏花素组小鼠血清IFN-λ和IL-2均升高。结论:乳腺癌手术切除后机体的免疫功能恢复对控制转移和复发十分重要。灯盏花素能促进机体免疫功能的恢复,因此可以用于预防乳腺癌术后转移和复发。
Objective: To observe the effect of breviscapine on the metastasis and recurrence of mouse breast cancer after surgical resection. Methods: Mouse 4T1 breast cancer cells were implanted under the mammary fat pad of female BALB / c mice. Breast cancer is surgically removed at a diameter of 10 mm and the next day treatment begins, including breviscapine, doxorubicin and radiotherapy. The therapeutic effect was evaluated by the postoperative metastasis and relapse rate, the serum levels of IFN-λ and IL-2, and the survival time of mice. Results: The recurrence rates of breast cancer in control group, doxorubicin chemotherapy group, radiotherapy and breviscapine group were 50%, 100%, 100% and 20% respectively. The metastatic rates in lung were 70%, 100% 100% and 20%. Compared with the control group, the serum adriamycin-λ and IL-2 in adriamycin-treated group and radiotherapy-treated mice were significantly lower, while the serum levels of IFN-λ and IL-2 in breviscapine group were significantly increased. Conclusion: The recovery of immune function after surgical resection of breast cancer is very important for the control of metastasis and recurrence. Breviscapine can promote the recovery of immune function, so it can be used to prevent postoperative metastasis and recurrence of breast cancer.