十字花科植物菘蓝(Isatis tinctoria)为传统染料和药用植物,用于治疗创伤、溃疡、肿瘤、痔疮、蛇咬伤和各种炎性疾病。从该植物的不同部位中已分离出约100种化合物,包括吲哚类生物碱、人工靛青染料及其前体、蒽衍生物、芥子油苷和其它有机硫化合物、氨基酸、萜类、核苷、苷类、芳香脂肪族羧酸和黄酮类。为了证实菘蓝作为抗炎药物的可能性,本次制备了多种菘蓝提取物,用直接对抗16个炎性靶点进行了体外筛选。 The cruciferous plant Isatis tinctoria is a traditional dye and medicinal plant used to treat wounds, ulcers, tumors, acne, snake bites and various inflammatory diseases. About 100 compounds have been isolated from different parts of the plant, including terpenoid alkaloids, artificial indigoid dyes and their precursors, indole derivatives, glucosinolates and other organic sulfur compounds, amino acids, terpenoids, nucleosides , glycosides, aromatic aliphatic carboxylic acids and flavonoids. In order to confirm the possibility of indigo as an anti-inflammatory drug, a variety of indigo extracts were prepared and screened in vitro against 16 inflammatory targets.