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目的研究人胃癌淋巴管的密度和面积及其与淋巴结转移的关系。方法采用D2-40淋巴管内皮标记性抗体免疫组织化学染色方法,检测70例人胃癌中心区、癌旁区、正常区内的淋巴管,分析淋巴管的形态学特征与淋巴结转移及其他临床病理因素之间的关系。结果人胃癌癌旁区淋巴管密度高于正常区,平均面积、平均周径及总面积小于正常区,差异均有统计学意义。淋巴结转移组人胃癌癌旁区淋巴管密度及平均面积、平均周径均高于无淋巴结转移组。结论人胃癌淋巴管新生存在于胃癌癌旁区,新生淋巴管管腔小,不足以形成良好的淋巴回流;人胃癌癌旁区淋巴管密度、平均面积与淋巴结转移有关,有望成为预测淋巴结转移及决定手术方式的重要因素。
Objective To study the density and area of lymphatic vessels in human gastric cancer and its relationship with lymph node metastasis. Methods D2-40 lymphatic endothelium-labeled antibody immunohistochemical staining method was used to detect the lymphatic vessels in 70 cases of central gastric cancer, paracancer area and normal area, and to analyze the morphological features of lymphatic vessels and lymph node metastasis and other clinicopathological features The relationship between factors. Results The lymphatic vessel density in paracancer area was higher than that in normal area, the average area, the average circumference and the total area were less than those in normal area. The differences were statistically significant. The lymphatic vessel density, the average area and the average circumference of gastric cancer adjacent to lymph node metastasis group were higher than those without lymph node metastasis group. Conclusion Lymphangiogenesis of human gastric cancer is located in the paracancer region of gastric cancer and the lymphatic lumen is small enough to form a good lymphatic circulation. The density and the average area of lymphatic vessels in the paracancer region of human gastric cancer are related to lymph node metastasis, Important factors that determine the surgical approach.