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[目的]研究胃癌组织中微淋巴管密度(MLD)与临床病理因素之间的关系。[方法]应用免疫组化方法检测52例胃癌病人的癌组织中D2-40的表达和微淋巴管的计数。[结果]胃癌组织中MLD值显著高于癌旁正常组织,与肿瘤浸润深度、临床分期无显著相关性(P>0.05)。但是与组织学分型及淋巴道转移密切相关(P<0.05)。[结论]胃癌组织中微淋巴管可能促进肿瘤淋巴道转移,胃癌组织中微淋巴管密度可作为评估淋巴道转移的一个指标。
[Objective] To study the relationship between micro-lymphatic vessel density (MLD) and clinicopathological factors in gastric cancer. [Method] The expression of D2-40 and lymphatic vessel count in 52 cases of gastric cancer were detected by immunohistochemistry. [Results] The MLD value of gastric cancer tissues was significantly higher than that of adjacent normal tissues, and had no significant correlation with the depth of invasion and clinical stage (P> 0.05). However, it was closely related to histological classification and lymphatic metastasis (P <0.05). [Conclusion] The lymphatic vessels in gastric cancer may promote lymphatic metastasis, and the lymphatic vessel density in gastric cancer may be used as an index to evaluate lymphatic metastasis.