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本文报告广东地区0—54岁白血病病人Hp~1频率显著高于正常人,其相对危险率为1.9,提示这一地区Hp~1基因与白血病发生有关。急粒和急淋组Hp~1频率显著高于正常人,慢粒组则与正常人无显著差异。化疗后的急拉和急淋组Hp2-2型和Hp2-1型Hp平均含量较化疗前显著降低,Hp1-1型则降低不显著;慢粒组三类Hp平均含量化疗前后无明显变化。提示Hp~1基因可能与急性白血病发生有关。具有Hp纯合子或杂合子正常母亲的白血病子女中,纯合子与杂合子的比例符合预期比例,提示在白血病病人家庭中Hp的遗传方式无异常。还观察到,肝癌中Hp~1频率亦显著增高,提示Hp~1基因除与白血病有关外,还可能与其他某些肿瘤的发生有关。
This report reports that the frequency of Hp ~ 1 in patients with leukemia from 0 to 54 years old in Guangdong is significantly higher than that in normal people, and the relative risk is 1.9, suggesting that the Hp ~ 1 gene in this area is related to leukemia. The frequency of Hp ~ 1 in acute pellet and acute pellet group was significantly higher than that in normal control group, but there was no significant difference between chronic pellet group and normal group. The average content of Hp2-2 and Hp2-1 Hp in the acute and acute leiomyelitis group after chemotherapy was significantly lower than that before chemotherapy, while the Hp1-1 type was not significantly reduced. The average content of Hp2-2 and Hp2-1 did not change significantly before and after chemotherapy. Tip Hp ~ 1 gene may be related to the occurrence of acute leukemia. Among leukemia children with Hp homozygous or heterozygous normal mothers, the proportion of homozygotes to heterozygotes was in line with expected proportions, suggesting that there is no abnormality in the genetic pattern of Hp in families of leukemia patients. It was also observed that the frequency of Hp ~ 1 in hepatocellular carcinoma was also significantly increased, suggesting that Hp ~ 1 gene in addition to leukemia, but also may be associated with the occurrence of some other tumors.