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分泌型IgA (SIgA)是机体外分泌中主要的免疫球蛋白,主要存在于鼻和支气管分泌物、唾液,初乳、泪液、胃肠液中。分泌型IgA参与呼吸道粘膜的免疫功能,在粘膜局部发挥抗细菌和病毒的作用,Yodfat等的研究证实上呼吸道感染时鼻分泌物中产生较高的SIgA,以保护粘膜抵抗感染。South证实SIgA缺乏或减低时易罹患上呼吸道感染。但SIgA在鼻部变态反应性疾病中的作用和意义还不清楚,其量有无增减也无定论。为探讨上
Secreted IgA (SIgA) is the major immunoglobulin in the body exocrine secretions, mainly in the nasal and bronchial secretions, saliva, colostrum, tears, gastrointestinal fluids. Secretory IgA is involved in the immune function of the respiratory mucosa, exerting anti-bacterial and viral effects locally on the mucosa. Studies by Yodfat et al. Have confirmed that higher SIgA is produced in nasal secretions during upper respiratory infections to protect the mucosa against infection. South confirmed that SIgA deficiency or reduced susceptibility to upper respiratory tract infection. However, the role and significance of SIgA in nasal allergic diseases is unclear, and there is no conclusion as to whether the amount of SIgA is increased or decreased. For discussion