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目的:观察喜炎平联合妈咪爱治疗婴幼儿秋季腹泻的疗效及安全性。方法:将秋季腹泻患儿64例随机分为2组各32例,2组均给予纠正脱水,维持电解质、酸碱平衡,对症治疗,对照组口服微生态制剂,呕吐停止后口服思密达保护胃肠黏膜。治疗组在对照组的基础上给予喜炎平联合妈咪爱口服。观察2组临床疗效以及相关指标变化。结果:总有效率治疗组为93.75%,对照组为71.88%,2组比较,差异有显著性意义(P<0.05)。治疗组患儿退热时间、止吐时间和止泻时间与对照组比较,差异均有显著性意义(P<0.05)。2组治疗后血清白细胞介素-6(IL-6)、IL-8、肿瘤坏死因子-α(TNF-α)水平均降低(P<0.05,P<0.01)。治疗后2组间比较,差异均有显著性意义(P<0.05)。结论:喜炎平联合妈咪爱治疗婴幼儿秋季腹泻,能明显缩短患儿症状消退时间,明显降低患儿的血清炎性因子水平,疗效确切,安全可靠,值得推广。
Objective: To observe the efficacy and safety of Xiyanping combined mommy love in treating infantile autumn diarrhea. Methods: 64 children with diarrhea in autumn were randomly divided into two groups (n = 32 in each group). Both groups were given dehydration, electrolytes, acid-base balance and symptomatic treatment. The control group received oral probiotics, Gastrointestinal mucosa. Treatment group in the control group based on the combination of Xiyanping mommy love oral. The clinical efficacy and the changes of related indexes in the two groups were observed. Results: The total effective rate was 93.75% in the treatment group and 71.88% in the control group. There was significant difference between the two groups (P <0.05). The treatment group, children with antipyretic time, antiemetic and antidiarrheal time compared with the control group, the difference was significant (P <0.05). The levels of serum IL-6, IL-8 and TNF-α in the two groups were decreased (P <0.05, P <0.01). After treatment, the differences between the two groups were significant (P <0.05). Conclusion: Xiyanping combined mommy love treatment of infantile autumn diarrhea, can significantly shorten the symptoms of children subsided time, significantly reduce the level of serum inflammatory cytokines in children, the exact effect, safe and reliable, it is worth promoting.