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肺栓塞(PE)的程度与其产生的症状并不一致。大的栓塞可无任何症状,而小的栓塞有严重血气异常和症状者也不少见,这可能与PE的栓子释放的支气管和血管活性物质有关,血小板活化因子(PAF)则是其中之一。为确定PAF在PE中的可能作用,观察吸入PAF对患者气道反应的影响。对新入院的下肢深静脉血栓形成患者做通气灌注肺扫描,发现24例既往有PE发作,其中12例在急性发作时曾有急性呼吸功能不全,另12例无症状。全部
The degree of pulmonary embolism (PE) and its symptoms are not consistent. Large embolization can be asymptomatic and small embolization with severe blood gas abnormalities and symptoms is not uncommon, which may be related to the release of bronchial and vasoactive substances by PE emboli, of which platelet activating factor (PAF) is one of them . To determine the possible role of PAF in PE, we investigated the effects of inhaled PAF on airway response in patients. Ventilation perfusion lung scan was performed on newly admitted patients with deep venous thrombosis of the lower extremity and found that there were 24 previous episodes of PE. Of these, 12 had acute respiratory insufficiency during the acute episode and the other 12 asymptomatic. All