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A fast method of liquid chromatography coupled to tandem mass spectrometry(LC-MS/MS) was developed for the analysis of eleven UV ink photoinitiators in packaged food.Chromatographic separation was achieved in a pentafluorophenylpropyl (PFPP) column at 5X2 and acetonitrile:25mM formic acid-ammonium formate(pH 2.7) in gradient elution. To reduce sample treatment,a QuEChERS(quick,easy,cheap,effective,rugged and safe) method for the extraction and clean-up of UV photoinitiators in packaged foods was evaluated.Triple quadrupole working in H-SRM on Ql mode was used for both quantitation and confirmation purposes and the most intense and selective transitions were chosen.Quality parameters of the developed QuEChERS LC-MS/MS method were established and applied for the analysis of photoinitiators in food packaged at ng/kg levels.
A fast method of liquid chromatography coupled to tandem mass spectrometry (LC-MS / MS) was developed for the analysis of eleven UV ink photoinitiators in packaged food. Chromatographic separation was achieved in a pentafluorophenylpropyl (PFPP) column at 5X2 and acetonitrile: 25 mM formic acid-ammonium formate (pH 2.7) in gradient elution. To reduce sample treatment, a QuEChERS (quick, easy, cheap, effective, rugged and safe) method for the extraction and clean-up of UV photoinitiators in packaged foods was evaluated. Triple quadrupole working in H-SRM on Ql mode was used for both quantitation and confirmation purposes and the most intense and selective transitions were chosen. Quality parameters of the developed QuEChERS LC-MS / MS method were established and applied for the analysis of photoinitiators in food packaged at ng / kg levels.